Pharmaceutical Manufacturing Process

1. Wet Granulation, Tabletting & Coating can be done by following wet mixing methods.

Powder- Row Material

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Grading & sieving Process (Machine – Vibro Sifter)

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Dry & Wet mixing with binder (Machine –High Shear Mixer OR Mass Mixer)
Starch Paste Preparation (Machine-Paste Making Kettle)

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Lumps Milling (Machine Multi mill / Cone Mill/Comminuting Mill / Oscillating Granulator)

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Wet Material Drying (Machine - Fluid Bed Drier OR Tray Dryer Oven)

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Forming Granules (M/c Multi mill / Cone Mill/Comminuting Mill / Oscillating Granulator)

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Grading & sieving (Machine – Vibro Sifter)

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Lubrication of granules for free flowing (M/c Blender Octagonal / Double & V Cone, Bin)

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Tablet Compression (Machine – Tablet Press & Die & Punch)
Tablet De Dusting (Machine – Vibro De Duster)
Powder dust extracting during tablet compression (Dust Extractor Unit)

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Film & Sugar Coating of tablets (Machine – Auto Coater or Conventional coating)
Coating solution preparation (Machine – Stirrer & Colloid Mill)

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After That Tablets will be inspected and Packed

2. Wet Granulation, Tabletting & Coating can be done by following direct drugs Penetration methods.

Process: 2 Wet granulation with Fluid Bed Processor with Top Spraying System
Powder- Row Material

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Grading & sieving Process (Machine – Vibro Sifter)

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Dry & Wet mixing & Granulation with Ingredient & Binder Spraying (M/c. –Fluid Bed Processor with Top Spray)

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Lumps Milling (Machine Multi mill / Cone Mill/)

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Grading & sieving (Machine – Vibro Sifter)

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Forming Granules (M/c Multi mill / Cone Mill/Comminuting Mill / Oscillating Granulator)

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Grading & sieving (Machine – Vibro Sifter)

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Lubrication of granules for free flowing (M/c Blender Octagonal / Double & V Cone, Bin Blender)

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Tablet Compression (Machine – Tablet Press & Die & Punch)
Tablet De Dusting (Machine – Vibro De Duster)
Dust extracting during tablet compression (Dust Extractor Unit)

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Film & Sugar Coating of tablets (Machine – Auto Coater or Conventional coating)
Coating solution preparation (Machine – Stirrer & Colloid Mill)

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After That Tablets will be inspected and Packed

3. Dry Granulation, Tabletting & Coating can be done by following direct Compaction methods.

Process: 2 Dry Granulation with Roll Compactor System
Powder- Row Material

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Grading & sieving Process (Machine – Vibro Sifter)

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Dry Compaction of the material (Machine – Roll Compactor)

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Compacted material to be granulated (M/c. Oscillating Granulator/Multi Mill)

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Grading & sieving (Machine – Vibro Sifter)

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Lubrication of granules for free flowing (M/c Blender Octagonal / Double & V Cone / Bin)

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Tablet Compression (Machine – Tablet Press & Die & Punch)
Tablet De Dusting (Machine – Vibro De Duster)
Dust extracting during tablet compression (Dust Extractor Unit)
OR
Granules Direct will be packed.

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Film & Sugar Coating of tablets (Machine – Auto Coater or Conventional coating)
Coating solution preparation (Machine – Stirrer & Colloid Mill)

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After That Tablets will be inspected and Packed

4. Pallets Making Process-1: In this process we manufactured equal size pallet for Pharmaceuticals and Foods.

Powder- Row Material

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Mixed the powder with liquid and made dough (Machine –Sigma Mixer-“Z” Blade Mixer)

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Mixed dough material to be extruded (M/c. – Extruder- Axial or Redial type )

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Spherical pallet made from Extruded material (Machine - Spherodizer)

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Spherical Pallet Drying (Machine – Fluid Bed dryer OR Tray Dryer)

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Grading & sieving (Machine – Vibro Sifter)

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After That Pallets are inspected and Packed in capsule
OR Packed in Pouch OR Will be pallet coated.

5. Pallets Making Process-2: In this process we manufactured unequal size pallet for Agro chemicals, Chemicals & Catalysts Industries.

Powder- Row Material

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Dry powder rotated on inclined disc type pan and that time liquid spray on the material so powder agglomerated and than agglomerated granules rolling and get size bigger due to continually spraying. In this process we get unequal size pallet. (M/c. –Palletizer)

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Pallet Drying (Machine – Fluid Bed dryer & Tray Dryer)

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Grading & sieving (Machine – Vibro Sifter)

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After those Pallets are inspected and packed in Bag.

6. Pallets Coating Process: In this process we coated automatically equal size pallets for Pharmaceuticals and Foods.

Equal size Pallets made form Process of Extruder & Spherodizer system.

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The pallet fill in the container of Fluid Bed Coater and spraying the coating solution by bottom spraying system and the will be dried the pallet in the same machine.(Machine – Fluid Bed Coater with Wurster Coater/ Bottom spraying system.)

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Grading & sieving (Machine – Vibro Sifter)

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After That Pallets are inspected and Packed in capsule
OR Packed in Pouch OR Will be pallet coated.

7. Liquid Syrup Manufacturing Automatic Process.

Process: 1 Automatic Sugar Syrup Manufacturing Process

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Step:1 Sugar Grading & sieving Process (Machine – Vibro Sifter)

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Step:2 Sugar Transfer in the sugar melting vessel (Machine – Vacuum Transfer System)

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Step:3 Sugar Melting Process by Sugar and D.M.water mixed and heated in sugar melting vessel so sugar is malted (Machine –Sugar Melting Vessel)

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Step:4 Melted Sugar to be filtered for removing impurity of solid particles and transfer the manufacturing vessel (M/c. Basket Filter and Transfer Pump)

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Step:5 Syrup manufacturing by adding drugs & ingredient in malted sugar and mixed by stirrer and high speed homogenizer with heating. Also the material re circulated in the vessel after that readiness of syrup it will be cooled by cooling system. (Machine –Syrup Manufacturing Vessel)

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Step:6 Cooled syrup will be transfer through inline homogenizer and filter press for homogenize mixing and filtered up to 5 microns size in storage tank. (M/c Inline Homogenizer & Filter Press)

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Step:7 The syrup is storage in the storage vessel and when transfer to the filling machine that time mixed by stirrer. (Machine –Storage Tank)

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Step:8 Syrup transfer to float tank of filling machine by transfer Pump system (Machine – Tranfer Pump)

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Liquid syrup will be packed in bottle by filling & sealing & packing line machinery

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Step: 9 Automatic washing of all vessel and Tank by CIP system (Machine –CIP/ WIP System)

8. Liquid Syrup Manufacturing Semi Automatic Process.

Process: 1 Semi Automatic Sugar Syrup Manufacturing Process

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Step:1 Sugar Grading & sieving Process (Machine – Vibro Sifter)

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Step:2 Sugar Transfer in the sugar melting vessel by Manually

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Step:3 Sugar Melting Process by Sugar and D.M.water mixed and heated in sugar melting vessel so sugar is malted than adding drugs & ingredient and mixed by stirrer in the same vessel for manufacturing syrup (Machine –Manufacturing Vessel)

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Step:4 The syrup will be transfer to storage vessel through inline filter press and than cool the syrup in storage vessel.(M/c Filter Press and Storage vessel)

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Step:5 The syrup is storage in the storage vessel and when transfer to the filling machine that time mixed by stirrer in the storage vessel and passed through Colloid mill for homogenize mixing. (Machine –Colloid Mill)

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Step:6 Syrup transfer to float tank of filling machine by transfer Pump system (Machine – Tranfer Pump)

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Liquid syrup will be packed in bottle by filling & sealing & packing line machinery

9. Ointment/ Cream / Tooth Paste /Gel Manufacturing Automatic Process.

Step:1 Water Phase: Fill D.M. water in water phase vessel than heated and stirring(Water Phase Vessel with stirrer & jacketed)

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Step:2 Wax Phase: Fill wax in wax phase vessel than heated and stirring (Wax Phase Vessel with stirrer & jacketed)

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Step:3 Melted wax and heated water will be transfer to in the Ointment/ Cream/ Tooth Paste/Gel Manufacturing Vessel by Vacuum Transfer system and mixed in the vessel. Than added drugs and ingredient with Heating, stirring and high speed homogenizer. Also the material re circulated in the vessel and Vacuumised for evaporate of the d (Machine –Ointment Manufacturing Jacketed Vessel with stirrer, High speed Homogenizer, Vacuum Pump and lid lifting system)

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Step:4 The material will be transfer to inh the storage tank by bump pump (M/c. Bump Pump)

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Step:5 The material will be store in the storage tank and this tank having facility for heating and trolley wheel for move to filling area. (Machine –Storage Tank)

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Step:6 The storage tank carry to filling machine by manually and the material will be heated by hot water circulation for easy transferring high viscous material by metering pump to the hopper of filling machine . (M/c- Metering Pump)

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Step:7 The Ointment/ Cream will be fill and seal by filling machine and packed by packing line machinery. (Machine –Filling & Sealing and Packing Line Machinery)

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Ointment / Cream will be packed by filling & sealing & packing line machinery

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Step: 8 Automatic washing of all vessel and Tank by CIP system (Machine –CIP/ WIP System)

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Please Note that the Triple Roller Mill will be used for proper mixing and reduced particle size of basic powder material and removing water and liquid content from final materials

10. Ointment/ Cream / Tooth Paste /Gel Manufacturing Semi Automatic Process.

Step:1 Water Phase & Wax Phase & Manufacturing Phase: Fill D.M. water in than heated and stirring after that added wax in the same container than again stirring and heated. After complete melting and mixing of wax than to be added drugs and ingredient in same container and mixed by stirrer.(Machine: Planetary Mixer with stirrer & jacketed)

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Step:2 The Mixed material will be passed through colloid mill for particles size reduction and homogenize mixing than transfer to storage tank..(Machine: Colloid Mill)

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Step:3 The material will be store in the storage tank and this tank having facility for heating and trolley wheel for move to filling area. (Machine –Storage Tank)

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Step:4 The storage tank carry to filling machine by manually and the material will be heated by hot water circulation for easy transferring high viscous material by metering pump to the hopper of filling machine . (M/c- Metering Pump)

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Step:5 The Ointment/ Cream will be fill and seal by filling machine and packed by packing line machinery. (Machine –Filling & Sealing and Packing Line Machinery)

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Ointment/ Cream will be packed by filling & sealing & packing line machinery

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Please Note that the Triple Roller Mill will be used for proper mixing and reduced particle size of basic powder material and removing water and liquid content from final materials.

11. For Material Transfer and Conveying Process.

A. We have Vacuum transfer system for following process

1. Loading sugar in sugar melting vessel.
2. Loading all type of Mixer machine.
3. Inline milling and sifting.
4. Loading all type of Blender machine.
5. Loading on Tablet Press.
6. Loading Tablet in coating Pan
7. Unloading FBD Bowl
8. Inline dry granulation with Roll Compactor. Oscillating Granulator and sifter

B. We have Tipper system for following process

1. Unloading FBD Bowl with inline milling or sifting.

C. We have Bin Loader system for following process

1. Loading all type of Mixer machine.
2. Loading Powder to the Tablet press.
3. Loading Tablet in Coating Pan
4. Inline milling and sifting of the materials.

D. We have Storage Bin / IPC Bin system for following process

1. Storage of powder, Granules. Tablets, Coated Tablets.
2. Transfer ingredient etc.

Our Range of machinery for different Process:

1. POWDER MIXING PROCESS

(a) Wet Mixing:

-> High Shear Mixer ( RMG)
-> Mass Mixer
-> Sigma Mixer ( Dough Mixing)
-> Paddle Mixer

(b) Dry Mixing:

-> Paddle Mixer
-> Ribbon Mixer
-> Cone Mixer

2. WET POWDER DRYING PROCESS

-> Fluid Bed Dryer
-> Tray dryer- Oven

3. VACUUMIZED DRYING PROCESS

-> ROTO CONE VACUUM DRYER
-> VACUUMIZED TRAY DRYER
-> VACUUMIZED RIBBON/PADDLE MIXER

4. FLUDIZED GRANULATION & PALLET COATER PROCESS

-> Fluid Bed Equipment with top spray and wurster coater- Combo Model.

5. PALLETS MAKING PROCESS

-> Sigma Mixer ( Dough Mixing)
-> Extruder
-> Spherodizer
-> Palletizer

6. DRY GRANULATION PROCESS

-> Roll Compactor
-> Oscillating Granulator

7. MILLING AND SIZE REDUCTION PROCESS

-> Multi Mill
-> Cone Mill
-> Comminuting Mill
-> Oscillating Granulator

8. STARCH PASTE MAKING PROCESS

-> Paste Kettle

9. BLENIDNG PROCESS

-> Octagonal Blender
-> “V” Shape Blender
-> Double Cone Blender
-> Bin/ Conta / Cage Blender
-> Tumbler Blender

10. SIEVING AND GRADING PROCESS

-> Vibro sifter

11. MATERIAL CONVEYING & STORAGE PROCESS

-> Tipper for FBD Bowl unloading
-> Bin Loader for RMG/Tablet Press/ Blister Pack/ Coating
-> Movable Hoist
-> Bin- Storage & Conveying
-> Pneumatic/ Vacuum Conveying System
-> Conveying Trolley
-> Air locked can for drugs convying

12. TABLETTING PROCESS

-> Tablet Press

13. TABLET ALLIED MACHINERY

-> Die and Punch
-> Die and Punch Storage Cabinet
-> Die and Punch Polishing Kit
-> Deduster
-> Elevating Deduster
-> Dust Extractor
-> Metal Detector

14. TABLET COATING PROCESS

(a) Film Coating

-> Auto Coater – Option for Interchangeable Pan

(b) Sugar Coating

-> Conventional Coating machine
-> Spraying system

(c) Coating Solution Preparation

-> Stirrer/ Homogenizer
-> Colloid Mill

15. LIQUID/SYRUP HOMOGINIZE MIXING & GRINDING PROCESS

-> Automatic Liquid Syrup Manufacturing Plant.
-> Colloid Mill
-> Stirrer
-> Homogenizer
-> Inline Homogenizer
-> Dispohomoginizer
-> Filter Press- Sparkles
-> Contra Mixer
-> Mixing Vessel - Vacuum/Jacketed-Heated /stirrer
-> Storage Tank with stirrer
-> Filter Press- Zero Holdup
-> Basket Filter
-> Telescopic Stand for stirrer

16. OINTMENT / CREAM HOMOGINIZE MIXING & GRINDING PROCESS

-> Colloid Mill
-> Homogenizer
-> Inline Homogenizer
-> Dispohomoginizer
-> Triple Roller Mill ( Three roller Mill)
-> Planetary Mixer
-> Vacuum Mixer
-> Ultra/Contra Mixer
-> Automatic Ointment / Cream / Tooth Paste / Gel Manufacturing Plant
-> Vacuumized Mixer with homogenizer

17. LIQUID-SOLID SEGRICATION PROCESS

-> Centrifuge

18. POWDER FINE PARTICAL SIZE REDUCTION PROCESS

-> Ball Mill
-> Pulverizer
-> Disintegrator
-> Kharal ( semi Liquid process) – for herbals product

Pharmaceutical Manufacturing Process

Pharmaceutical Manufacturing Process

Pharmaceutical Manufacturing Process

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